Acute and chronic hypoxia differentially predispose lungs for metastases.
Sci Rep. 2019 Jul 15;9(1):10246
Authors: Reiterer M, Colaço R, Emrouznejad P, Jensen A, Rundqvist H, Johnson RS, Branco C
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.
Cell Stem Cell. 2019 Sep 05;25(3):407-418.e6
Authors: Ho YH, Del Toro R, Rivera-Torres J, Rak J, Korn C, García-García A, Macías D, González-Gómez C, Del Monte A, Wittner M, Waller AK, Foster HR, López-Otín C, Johnson RS, Nerlov C, Ghevaert C, Vainchenker W, Louache F, Andrés V, Méndez-Ferrer S
Correlates of light physical activity among cancer survivors.
Psychooncology. 2019 04;28(4):726-734
Authors: Johnson RS, Fallon EA, Berg CJ
Hypoxia-inducible factor controls immunoregulatory properties of myeloid cells in mouse cardiac allografts - an experimental study.
Transpl Int. 2019 01;32(1):95-106
Authors: Keränen MAI, Raissadati A, Nykänen AI, Dashkevich A, Tuuminen R, Krebs R, Johnson RS, Syrjälä SO, Lemström KB
Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha.
Front Physiol. 2018;9:1624
Authors: Fitzpatrick SF, Gojkovic M, Macias D, Tegnebratt T, Lu L, Samén E, Rundqvist H, Johnson RS
Nat Commun. 2018 10 16;9(1):4181
Authors: Pitt JJ, Riester M, Zheng Y, Yoshimatsu TF, Sanni A, Oluwasola O, Veloso A, Labrot E, Wang S, Odetunde A, Ademola A, Okedere B, Mahan S, Leary R, Macomber M, Ajani M, Johnson RS, Fitzgerald D, Grundstad AJ, Tuteja JH, Khramtsova G, Zhang J, Sveen E, Hwang B, Clayton W, Nkwodimmah C, Famooto B, Obasi E, Aderoju V, Oludara M, Omodele F, Akinyele O, Adeoye A, Ogundiran T, Babalola C, MacIsaac K, Popoola A, Morrissey MP, Chen LS, Wang J, Olopade CO, Falusi AG, Winckler W, Haase K, Van Loo P, Obafunwa J, Papoutsakis D, Ojengbede O, Weber B, Ibrahim N, White KP, Huo D, Olopade OI, Barretina J
The role of Olfr78 in the breathing circuit of mice.
Nature. 2018 09;561(7724):E33-E40
Authors: Torres-Torrelo H, Ortega-Sáenz P, Macías D, Omura M, Zhou T, Matsunami H, Johnson RS, Mombaerts P, López-Barneo J
Transpl Int. 2019 01;32(1):95-106
Authors: Keränen MAI, Raissadati A, Nykänen AI, Dashkevich A, Tuuminen R, Krebs R, Johnson RS, Syrjälä SO, Lemström KB
HIF-2α is essential for carotid body development and function.
Elife. 2018 04 19;7:
Authors: Macias D, Cowburn AS, Torres-Torrelo H, Ortega-Sáenz P, López-Barneo J, Johnson RS
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia.
Cell Metab. 2018 04 03;27(4):898-913.e7
Authors: Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macías D, Bargiela DM, Pietsch S, Gralla M, Evans CE, Kittipassorn T, Chey YCJ, Branco CM, Rundqvist H, Peet DJ, Johnson RS
Cancer Cell. 2017 11 13;32(5):669-683.e5
Authors: Palazon A, Tyrakis PA, Macias D, Veliça P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, Johnson RS
Cardiovascular adaptation to hypoxia and the role of peripheral resistance.
Elife. 2017 10 19;6:
Authors: Cowburn AS, Macias D, Summers C, Chilvers ER, Johnson RS
Metabolic basis to Sherpa altitude adaptation.
Proc Natl Acad Sci U S A. 2017 06 13;114(24):6382-6387
Authors: Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ
A Molecular Mechanism To Switch the Aryl Hydrocarbon Receptor from a Transcription Factor to an E3 Ubiquitin Ligase.
Mol Cell Biol. 2017 07 01;37(13):
Authors: Luecke-Johansson S, Gralla M, Rundqvist H, Ho JC, Johnson RS, Gradin K, Poellinger L
Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.
Sci Immunol. 2017 Feb 10;2(8):
Authors: Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR
Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis.
Biol Open. 2017 May 15;6(5):688-697
Authors: Evans CE, Palazon A, Sim J, Tyrakis PA, Prodger A, Lu X, Chan S, Bendahl PO, Belting M, Von Euler L, Rundqvist H, Johnson RS, Branco C
Cutaneous exposure to hypoxia does not affect skin perfusion in humans.
Acta Physiol (Oxf). 2017 07;220(3):361-369
Authors: Siebenmann C, Keramidas ME, Rundqvist H, Mijwel S, Cowburn AS, Johnson RS, Eiken O
To PFKFB3 or Not to PFKFB3, That Is the Question.
Cancer Cell. 2016 12 12;30(6):831
Authors: Branco C, Johnson RS
A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium.
Neuron. 2016 Dec 21;92(6):1196-1203
Authors: Bleymehl K, Pérez-Gómez A, Omura M, Moreno-Pérez A, Macías D, Bai Z, Johnson RS, Leinders-Zufall T, Zufall F, Mombaerts P
Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection.
Immunity. 2016 11 15;45(5):1024-1037
Authors: Phan AT, Doedens AL, Palazon A, Tyrakis PA, Cheung KP, Johnson RS, Goldrath AW
Cutaneous exposure to hypoxia does not affect skin perfusion in humans.
Acta Physiol (Oxf). 2017 07;220(3):361-369
Authors: Siebenmann C, Keramidas ME, Rundqvist H, Mijwel S, Cowburn AS, Johnson RS, Eiken O
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Nature. 2016 12 08;540(7632):236-241
Authors: Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Veliça P, You J, Chia GS, Sim J, Doedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW, Johnson RS
Autocrine VEGF Isoforms Differentially Regulate Endothelial Cell Behavior.
Front Cell Dev Biol. 2016;4:99
Authors: Yamamoto H, Rundqvist H, Branco C, Johnson RS
HIF2α-arginase axis is essential for the development of pulmonary hypertension.
Proc Natl Acad Sci U S A. 2016 08 02;113(31):8801-6
Authors: Cowburn AS, Crosby A, Macias D, Branco C, Colaço RD, Southwood M, Toshner M, Crotty Alexander LE, Morrell NW, Chilvers ER, Johnson RS
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Nat Commun. 2016 05 18;7:11635
Authors: Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I
Diverse roles of cell-specific hypoxia-inducible factor 1 in cancer-associated hypercoagulation.
Blood. 2016 Mar 10;127(10):1355-60
Authors: Evans CE, Bendahl PO, Belting M, Branco C, Johnson RS
Cutaneous control of blood pressure.
Curr Opin Nephrol Hypertens. 2016 Jan;25(1):11-5
Authors: Johnson RS, Titze J, Weller R